Let assume that I have the following directory structure: /var/www/html `- site_a `- site_b `- site_c `- multisites I want to install and enable wordpress multisites under multisites directory. But I cannot access to this directory, even after studying this Nginx official settings Here is my nginx.conf: map $uri $blogname{ ~^(?P<blogpath>/[^/]+/)files/(.*) $blogpath ; } map $blogname $blogid{ default -999; #Ref: http://wordpress.org/extend/plugins/nginx-helper/ #include /var/www/wordpress/wp-content/plugins/nginx-helper/map.conf ; } server { listen 80; listen [::]:80; server_name localhost.local; http2 on; index index.php index.html index.htm; proxy_buffer_size 256k; proxy_buffers 4 512k; proxy_busy_buffers_size 512k; proxy_max_temp_file_size 0; root /var/www/html; location ~* xmlrpc.php { deny all; return 404; } # https://www.nginx.com/resources/wiki/start/topics/recipes/wordpress/#rewrite-rules-for-multisite location ~* /multisites { index index.php; location ~ ^(/[^/]+)?/files/(.+) { try_files /wp-content/blogs.dir/$blogid/files/$2 /wp-includes/ms-files.php?file=$2 ; access_log off; log_not_found off; expires max; } #avoid php readfile() location ^~ /multisites/blogs.dir { internal; alias /var/www/html/multisites/wp-content/blogs.dir ; access_log off; log_not_found off; expires max; } if (!-e $request_filename) { rewrite_log on; rewrite /wp-admin$ $scheme://$host$uri/ permanent; rewrite ^(/[^/]+)?(/wp-.*) $2 last; rewrite ^(/[^/]+)?(/.*\.php) $2 last; } location / { try_files $uri $uri/ /index.php?$args ; } location ~ \.php$ { try_files $uri =404; include fastcgi_params; fastcgi_pass php:9000; } } location ~ ^/(site_a|site_b)/wp-json/ { # if permalinks not enabled rewrite ^/cms/wp-json/(.*?)$ /cms/?rest_route=/$1 last; } location ~ ^/(site_a|site_b)/ { root /var/www/html; try_files $uri $uri/ /$1/index.php$is_args$args; location ~* \.(?:ico|css|js|gif|jpe?g|png|svg)$ { expires 365d; add_header Pragma public; add_header Cache-Control "public"; } location ~ \.php$ { include fastcgi_params; fastcgi_pass php:9000; fastcgi_split_path_info ^(.+\.php)(/.+)$; fastcgi_index index.php; fastcgi_hide_header X-Powered-By; fastcgi_param SCRIPT_FILENAME /var/www/html/$fastcgi_script_name; fastcgi_param PATH_INFO $fastcgi_path_info; } } location ~ / { root /var/www/html; try_files $uri $uri/ index.php?$query_string; location ~* \.(?:ico|css|js|gif|jpe?g|png|svg)$ { expires 365d; add_header Pragma public; add_header Cache-Control "public"; } location ~ \.php$ { include fastcgi_params; fastcgi_pass php:9000; fastcgi_split_path_info ^(.+\.php)(/.+)$; fastcgi_index index.php; fastcgi_hide_header X-Powered-By; fastcgi_param SCRIPT_FILENAME /var/www/html/$fastcgi_script_name; fastcgi_param PATH_INFO $fastcgi_path_info; } } location ~ \.php$ { include fastcgi_params; fastcgi_pass php:9000; fastcgi_split_path_info ^(.+\.php)(/.+)$; fastcgi_index index.php; fastcgi_hide_header X-Powered-By; fastcgi_param SCRIPT_FILENAME /var/www/html/$fastcgi_script_name; fastcgi_param PATH_INFO $fastcgi_path_info; } } Can anyone please help me on this? Thank you for your help.